Is Dexedrine (Dextroamphetamine) A Controlled Substance?

Dexedrine is classified as a schedule II controlled substance because of it's high potential for abuse and can lead to psychological and physical dependence.

Is Dexedrine (Dextroamphetamine) A Controlled Substance?

Dexedrine is considered a controlled substance by the Drug Enforcement Administration (DEA) and the Food and Drug Administration (FDA).

Dexedrine is the brand name for dextroamphetamine, a central nervous system stimulant medication that is used to treat attention-deficit hyperactivity disorder (ADHD) and the sleep disorder narcolepsy.

This prescription stimulant works by increasing the amount of dopamine and norepinephrine in the brain. This increase can lead to a decrease in impulsivity and an increase in attention and focus.

Dexedrine As A Controlled Substance

Dexedrine is classified as a schedule II controlled substance under the Controlled Substances Act. This means it has a high potential for abuse and can lead to psychological and physical dependence.

This schedule also includes methamphetamines, Adderall (amphetamine/dextroamphetamine), and Ritalin (methylphenidate).

While the drug has a medical use, it’s controlled because of its high risk of abuse, and, when abused, it can be addictive and lead to serious health conditions.

Types Of Dexedrine

There are two types of Dexedrine: immediate-release and extended-release.

The immediate-release tablets are taken two to three times a day and are available in 5 mg doses.

The extended-release capsules are taken once a day and come in 5, 10, and 15 mg doses.

Both types of Dexedrine have the potential for abuse and are schedule II controlled substances.

Side Effects Of Dexedrine

Dexedrine, like most medications, also comes with a number of side effects. Some are more common than others and some are more serious than others.

The most common side effects of Dexedrine may include:

  • nausea
  • abdominal pain
  • loss of appetite
  • diarrhea
  • constipation
  • dry mouth
  • headache
  • increased heart rate
  • dizziness
  • trouble sleeping
  • sweating
  • weight loss
  • irritability

Dexedrine can also occasionally lead to serious side effects that may include:

  • numbness
  • sensitivity to temperature in the fingers or toes
  • aggressive behavior
  • depression
  • hallucinations
  • muscle twitching or shaking
  • blurred vision
  • outbursts of words or sounds
  • swelling of ankles or feet
  • extreme tiredness
  • sudden death

If you experience any of these serious side effects, contact your healthcare provider as soon as possible. They should be able to find another medication that will work for you.

Drug Interactions

There are also certain medications that shouldn’t be mixed with Dexedrine as they can lead to adverse reactions and cause serious health issues. Some of the medications that shouldn’t be taken with Dexedrine include:

  • antidepressant medicines including monoamine oxidase inhibitors (MAOIs)
  • blood pressure medicines
  • antacids
  • seizure medicines
  • some supplements

If you are on any of these medications, make sure the doctor prescribing you medication is aware before they put you on Dexedrine.


There are also several health conditions that don’t work well with Dexedrine. The drug can actually make these issues worse. If you have any of the following health problems or a history of these health problems, let your doctor know:

  • existing cardiovascular/heart problems like high blood pressure, chest pain, heart attack, or cardiomyopathy
  • glaucoma
  • history of substance abuse
  • allergy to amphetamines, other stimulant medications, or other ingredients in Dexedrine
  • history of psychosis or mental health issues like bipolar disorder, depression, and suicidal thoughts
  • history of tics or Tourette’s syndrome
  • thyroid problems
  • seizures
  • blood circulation problems

If you’re breastfeeding, you may also want to talk to your healthcare provider about if Dexedrine is the best option for you. It can transfer into your breast milk and to the baby.

Dexedrine Withdrawal Symptoms

If you abuse Dexedrine or take high doses for a long period of time, you have an increased risk of building a dependence on the prescription drug.

Once your body is dependent on Dexedrine, withdrawal symptoms are likely to occur when you stop use. Symptoms may include drug cravings, agitation, and fatigue.

If you or a loved one struggle with stimulant drug abuse, contact us today for information on our outpatient treatment options.

Written by
Northeast Addition Editorial Team

Published on

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This page does not provide medical advice.

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